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Catalytic asymmetric dearomative [4 + 2] annulation of 2-nitrobenzofurans and 5<i>H</i>-thiazol-4-ones: stereoselective construction of dihydrobenzofuran-bridged polycyclic skeletons

Jian‐Qiang Zhao, Zhou Shun, Zhen‐Hua Wang, Yong You, Shuang Chen, Xiong‐Li Liu, Ming‐Qiang Zhou, Wei‐Cheng Yuan

2021Organic Chemistry Frontiers36 citationsDOI

Abstract

An organocatalytic asymmetric dearomative [4 + 2] annulation of 2-nitrobenzofurans and 5 H -thiazol-4-ones is developed for the construction of dihydrobenzofuran-bridged polycyclic skeletons with good results.

Topics & Concepts

AnnulationChemistryStereoselectivityCatalysisStereochemistryCombinatorial chemistryMedicinal chemistryOrganic chemistryCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesAsymmetric Synthesis and Catalysis
Catalytic asymmetric dearomative [4 + 2] annulation of 2-nitrobenzofurans and 5<i>H</i>-thiazol-4-ones: stereoselective construction of dihydrobenzofuran-bridged polycyclic skeletons | Litcius