Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides
Bing-Zhi Fan, Hiroshi Hiasa, Wei Lv, Scott I. Brody, Zhao-yong Yang, Courtney C. Aldrich, Mark Cushman, Jian‐Hua Liang
Topics & Concepts
ChemistryQuinoloneDNA gyraseQuinolineCiprofloxacinTopoisomerase IVAzithromycinGatifloxacinStereochemistryDNA supercoilAntibioticsEscherichia coliBiochemistryDNADNA replicationOrganic chemistryGeneCancer therapeutics and mechanismsAntibiotic Resistance in BacteriaAntimicrobial Resistance in Staphylococcus