Bimetallic nanoplatform for synergistic sonodynamic-calcium overload therapy utilizing self-supplied hydrogen peroxide and relieved hypoxia
Wenqian Xu, Yisheng Zhao, Chao Zhang, Mengping Huo, Lei Wang, Xuewu Wu, Yang Zhang, Qiao Li, Yonghao Gai
Abstract
This study introduces a bimetallic nanoplatform (Fe 3 O 4 -TAPP@PVP-CaO 2 ) that addresses the limitations in sonodynamic therapy. It enhances oxygen supply, generates toxic reactive oxygen species, and triggers cancer cell death through calcium overload.
Topics & Concepts
Sonodynamic therapyBimetallic stripHydrogen peroxideHypoxia (environmental)ChemistryCalciumOxygenReactive oxygen speciesCatalysisBiochemistryOrganic chemistryNanoplatforms for cancer theranosticsPhotoacoustic and Ultrasonic ImagingAdvanced Nanomaterials in Catalysis