<i>In situ</i>photo-crosslinked adhesive hydrogel loaded with mesenchymal stem cell-derived extracellular vesicles promotes diabetic wound healing
Yixi Wang, Ping Song, Lina Wu, Zixuan Su, Xingyu Gui, Canyu Gao, Hanxing Zhao, Yu Wang, Zhengyong Li, Ying Cen, Bo Pan, Zhenyu Zhang, Changchun Zhou
Abstract
. In the skin wound model of diabetic rats, the GelMA-dopamine-EV hydrogel exerted prominent wound healing efficacy estimated by collagen deposition, skin appendage regeneration, and the expression of IL-6, CD31, and TGF-β. In conclusion, this combination of MSC-EVs and the modified hydrogel not only accelerates wound closure but also promotes skin structure normalization by rescuing the homeostasis of the healing microenvironment of diabetic wounds, which provides a potential approach for the treatment of diabetic wounds.
Topics & Concepts
Wound healingSelf-healing hydrogelsMesenchymal stem cellBiocompatibilityAngiogenesisSkin repairBiomedical engineeringRegeneration (biology)ChemistryMaterials scienceCell biologyMedicineCancer researchSurgeryBiologyOrganic chemistryWound Healing and TreatmentsMesenchymal stem cell researchPeriodontal Regeneration and Treatments