Recent advances in bacteria‐based platforms for inflammatory bowel diseases treatment
Jiaoying Lu, Xinyuan Shen, Hongjun Li, Juan Du
Abstract
Inflammatory bowel disease (IBD) is a recurring chronic inflammatory disease. Current treatment strategies are aimed at alleviating clinical symptoms and are associated with gastrointestinal or systemic adverse effects. New delivery strategies are needed for the treatment of IBD. Bacteria are promising biocarriers, which can produce drugs in situ and sense the gut in real time. Herein, we focus on recent studies of engineered bacteria used for IBD treatment and introduce the application of engineered bacteria in the diagnosis. On this basis, the current dilemmas and future developments of bacterial delivery systems are discussed.
Topics & Concepts
Inflammatory bowel diseaseMedicineDiseaseInflammatory Bowel DiseasesIntensive care medicineBacteriaAdverse effectImmunologyBiologyInternal medicineGeneticsCancer Research and TreatmentsBacteriophages and microbial interactionsGut microbiota and health