Salts, solvates and hydrates of the multi-kinase inhibitor drug pazopanib with hydroxybenzoic acids
K. Sunil, Debjani Baidya, Ashwini Nangia
Abstract
Eight cocrystal-salts of the multi-kinase drug pazopanib with hydroxybenzoic acids are sustained by the strong, ionic aminopyridinium⋯carboxylate heterosynthon of N–H⋯O hydrogen bonds between the carboxylic acid donor and amino-pyrimidine acceptor.
Topics & Concepts
CocrystalHydrogen bondChemistryPazopanibCarboxylatePyrimidineHydroxybenzoic acidStereochemistryCombinatorial chemistryOrganic chemistryMedicineMoleculeCancerInternal medicineSunitinibCrystal structures of chemical compoundsMetal complexes synthesis and propertiesQuinazolinone synthesis and applications