Enantioselective Palladium‐Catalyzed Hydrophosphinylation of Allenes with Phosphine Oxides: Access to Chiral Allylic Phosphine Oxides
Zhiping Yang, Jun Wang
Abstract
A Pd-catalyzed hydrophosphinylation of alkyl and aryl-oxyallenes with phosphine oxides has been developed for the efficient and rapid construction of a family of chiral allylic phosphine oxides with a diverse range of functional groups. This methodology was further applied in the facile construction of chiral 2H-chromene and later stage functionalization of cholesterol.
Topics & Concepts
PhosphineAllylic rearrangementEnantioselective synthesisArylCatalysisPalladiumAlkylChemistryOrganic chemistryCombinatorial chemistryOrganophosphorus compounds synthesisAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and Catalysis