Alterations in the Gut Microbiome and Metabolisms in Pregnancies with Fetal Growth Restriction
Zixin Tao, Yun Chen, Fang He, Jiawei Tang, Limei Zhan, Haoyue Hu, Ziling Ding, Shenghang Ruan, Yutao Chen, Beier Chen, Yan Wang, Xiaoling Guo, Liwei Xie, Mei Zhong, Qitao Huang
Abstract
Downstream of the primary cause of fetal growth restriction are placental insufficiency and fetal malnutrition. Gut microbiota and metabolites appear to play an important role in the progression of gestation, while dysbiosis induces maternal and fetal complications. Our study elaborates the significant differences in microbiota profiles and metabolome characteristics between women with FGR and normal pregnancies. This is the first attempt so far that reveals the mechanistic links in multi-omics in FGR, providing a novel insight into host-microbe interaction in placenta-derived diseases.