Direct activation of microglia by β-glucosylceramide causes phagocytosis of neurons that exacerbates Gaucher disease
Takashi Shimizu, Charles R. Schutt, Yoshihiro Izumi, Noriyuki Tomiyasu, Zakaria Omahdi, Kuniyuki Kano, Hyota Takamatsu, Junken Aoki, Takeshi Bamba, Atsushi Kumanogoh, Masaki Takao, Sho Yamasaki
Topics & Concepts
MicrogliaPhagocytosisMinocyclineTREM2Tumor necrosis factor alphaImmunologyBlockadeBiologyGlucocerebrosidaseDiseasePharmacologyInflammationCancer researchMedicineInternal medicineBiochemistryReceptorAntibioticsLysosomal Storage Disorders ResearchNeuroinflammation and Neurodegeneration MechanismsCalcium signaling and nucleotide metabolism