Litcius/Paper detail

Interstitial Collagen Loss, Myocardial Remodeling, and Function in Primary Mitral Regurgitation

Mustafa I. Ahmed, Efstathia Andrikopoulou, Jingyi Zheng, Elena Ulasova, Betty Pat, Eric E. Kelley, Pamela C. Powell, Thomas S. Denney, Clifton Lewis, James E. Davies, Victor Darley‐Usmar, Louis J. Dell’Italia

2022JACC Basic to Translational Science17 citationsDOIOpen Access PDF

Abstract

Interstitial collagen loss and cardiomyocyte ultrastructural damage accounts for left ventricular (LV) sphericity and decrease in LV twist and circumferential strain. Normal LV diastolic function belies significantly abnormal left atrial (LA) function and early LV diastolic untwist rate. This underscores the complex interplay of LV and LA myocardial remodeling and function in the pathophysiology of primary mitral regurgitation. In this study, we connect LA function with LV systolic and diastolic myocardial remodeling and function using cardiac magnetic resonance tissue tagging in primary mitral regurgitation.

Topics & Concepts

CardiologyInternal medicineFunctional mitral regurgitationMitral regurgitationDiastolic functionMedicineVentricular remodelingDiastoleCardiac magnetic resonancePathophysiologyHeart failureMagnetic resonance imagingEjection fractionBlood pressureRadiologyCardiac Valve Diseases and TreatmentsCardiovascular Function and Risk FactorsCardiac Structural Anomalies and Repair
Interstitial Collagen Loss, Myocardial Remodeling, and Function in Primary Mitral Regurgitation | Litcius