Platelet transfusion refractoriness and anti‐HLA immunization
Lucie Blandin, Aurore Dougé, Amandine Fayard, Jacques‐Olivier Bay, Guillaume Berlie, Bruno Pereira, Richard Lemal, Paul Rouzaire
Abstract
Platelet transfusion refractoriness (PTR), defined as an unsatisfactory post-transfusion platelet count increment, is a common complication of patients receiving multiple transfusions. Different strategies are described in the management of PTR. In this work, we demonstrate the efficacy of the detection and identification of anti-HLA antibodies in the recipient using a threshold of 3000 mean fluorescence intensity (MFI), and the seek of donors not expressing HLA antigens against which the patient is immunized.
Topics & Concepts
PlateletPlatelet transfusionMedicineHuman leukocyte antigenImmunizationComplicationImmunologyAntibodyBlood transfusionRefractory (planetary science)Refractory periodAntigenInternal medicineBiologyAstrobiologyBlood transfusion and managementBlood groups and transfusionPlatelet Disorders and Treatments