Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation
Filip Pidaný, Jana Křoustková, Abdullah Al Mamun, Daniela Suchánková, Xavier Brazzolotto, Florian Nachon, Fabien Chantegreil, Rafael Doležal, Lenka Pulkrabkova, Ľubica Múčková, Martina Hrabinová, Vladimír Finger, Martin Kufa, Ondřej Soukup, Daniel Jun, Jaroslav Jenčo, Jiřı́ Kuneš, Lucie Nováková, Jan Korábečný, Lucie Cahlíková
Topics & Concepts
ButyrylcholinesteraseChemistryAlkaloidCytotoxicityIC50Structure–activity relationshipAmaryllidaceaeStereochemistryLead compoundIn vitroChemical libraryCholinesteraseBiological activityEnzymeCombinatorial chemistryPharmacologyBiochemistrySmall moleculeAchéAcetylcholinesteraseBotanyBiologyMedicineChemical synthesis and alkaloidsCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery Methods