Development of a minimal physiologically-based pharmacokinetic/pharmacodynamic model to characterize target cell depletion and cytokine release for T cell-redirecting bispecific agents in humans
Xiling Jiang, Xi Chen, Pharavee Jaiprasart, Thomas Carpenter, Rebecca Zhou, Weirong Wang
Topics & Concepts
BlinatumomabCytokinePharmacodynamicsCytokine release syndromePharmacologyPharmacokineticsMedicineT cellImmunologyDosingImmune systemCD19Chimeric antigen receptorCAR-T cell therapy researchMonoclonal and Polyclonal Antibodies ResearchLymphoma Diagnosis and Treatment