Remodeling cancer stemness by collagen/fibronectin <i>via</i> the AKT and CDC42 signaling pathway crosstalk in glioma
Chuanhong Zhong, Bei Tao, Fangli Tang, Xiaobo Yang, Tangming Peng, Jian You, Kaiguo Xia, Xiangguo Xia, Ligang Chen, Lilei Peng
Abstract
We demonstrated that type I collagen and fibronectin could collaborate to promote glioma progression through PI3K/AKT/SOX2 and CDC42/YAP-1/NUPR1/Nestin signaling pathways. Blockade of the upstream molecular integrin αvβ3 revealed improved outcome in glioma therapy, which provide new insights for eradicating tumors and reducing glioma cancer relapse.
Topics & Concepts
FibronectinGliomaCancer researchExtracellular matrixPI3K/AKT/mTOR pathwayIntegrinTumor microenvironmentChemistryProtein kinase BTumor progressionBiologySignal transductionCell biologyCancerCellBiochemistryGeneticsTumor cellsCell Adhesion Molecules ResearchHippo pathway signaling and YAP/TAZCellular Mechanics and Interactions