PHLDA2 regulates EMT and autophagy in colorectal cancer via the PI3K/AKT signaling pathway
Zhan Ma, Shuping Lou, Zheng Jiang
Abstract
. The effects of PHLDA2 on autophagy and EMT were mediated in part via the PI3K/AKT signaling pathway. Taken together, these results suggest that downregulation of PHLDA2 inhibits tumor growth and PI3K, thereby promoting autophagy and inhibiting EMT, in part through the PI3K/AKT/mTOR and PI3K/AKT/GSK-3β signaling pathways.
Topics & Concepts
AutophagyPI3K/AKT/mTOR pathwayProtein kinase BCancer researchColorectal cancerSignal transductionCancerMedicineChemistryCell biologyBiologyInternal medicineApoptosisBiochemistryGenetic Syndromes and ImprintingEpigenetics and DNA MethylationAutophagy in Disease and Therapy