Butyrate-Rich Diets Improve Redox Status and Fibrin Lysis in Behçet’s Syndrome
Giacomo Emmi, Alessandra Bettiol, Elena Niccolai, Matteo Ramazzotti, Amedeo Amedei, Giuditta Pagliai, Niccolò Taddei, Francesco Sofi, Claudia Fiorillo, Domenico Prisco, Matteo Becatti
Abstract
Behçet’s syndrome (BS) is a rare neutrophilic vasculitis characterized by arterial and venous events, uniquely treated by immunosuppressants rather than anticoagulants. We demonstrated in BS an impaired fibrinogen structure and fibrin susceptibility to plasmin-induced lysis, mainly due to an enhanced neutrophils reactive oxygen species (ROS) production, supporting the notion that BS is a model of inflammation-induced thrombosis .
Topics & Concepts
FibrinHumanitiesMedicineLibrary scienceArtImmunologyComputer scienceOcular Diseases and Behçet’s SyndromeAutoimmune and Inflammatory Disorders ResearchInflammasome and immune disorders