Comparative analysis of piRNA sequences, targets and functions in nematodes
Benjamin Pastore, Hannah L. Hertz, Wen Tang
Abstract
Piwi mutants. Instead, we found that transcripts with few introns are prone to small RNA overamplification. Together our work highlights evolutionary conservation and divergence of the nematode piRNA pathway and provides insights into its role in endogenous gene regulation.
Topics & Concepts
Piwi-interacting RNABiologyRasiRNAGeneticsTransposable elementArgonauteSmall nucleolar RNAGeneSmall RNAIntronBiogenesisRNAEvolutionary biologyRNA interferenceGenomeNon-coding RNACRISPR and Genetic EngineeringChromosomal and Genetic VariationsGenetics, Aging, and Longevity in Model Organisms