Effects of Regulatory Network Organization and Environment on PmrD Connector Activity and Polymyxin Resistance in <i>Klebsiella pneumoniae</i> and <i>Escherichia coli</i>
Annie I. Chen, Francisco Javier Albicoro, Jun Zhu, Mark Goulian
Abstract
, PmrD functions as a connector between PhoQ/PhoP and PmrB/PmrA, in contrast with previous reports. In this case, activity also depends on PmrB/PmrA stimulation, or on very high activation of PhoQ/PhoP. Our results indicate that the importance of the PmrD connector in modulating the polymyxin resistance network depends on both the network organization and on the environmental conditions associated with PmrB stimulation.
Topics & Concepts
PolymyxinKlebsiella pneumoniaeEscherichia coliBiologyMicrobiologyPolymyxin BEnterobacteriaceaeAntimicrobial peptidesBacteriaGeneAntimicrobialGeneticsAntibiotic Resistance in BacteriaBacterial Genetics and BiotechnologyBacterial biofilms and quorum sensing