Antifungal Azoles as Tetracycline Resistance Modifiers in Staphylococcus aureus
Nisha Mahey, Rushikesh Tambat, Dipesh Kumar Verma, Nishtha Chandal, Krishan Gopal Thakur, Hemraj Nandanwar
Abstract
-based screen of clinically approved drugs that identified antifungal azoles inhibiting Tet(K), a pump that belongs to the major facilitator superfamily, and showed that these compounds bind to and block the activity of the Tet(K) pump. Azoles enhanced the susceptibility of tetracycline against S. aureus and its methicillin-resistant strains. The combination of azoles with tetracycline led to a significant reduction in preformed biofilms. Repurposing approved drugs may help solve the classical toxicity issues related to efflux pump inhibitors.
Topics & Concepts
EffluxStaphylococcus aureusMicrobiologyEthidium bromideTetracyclineAntibioticsBiofilmChemistryMultiple drug resistanceBiologyBacteriaBiochemistryGeneticsDNAAntifungal resistance and susceptibilityAntimicrobial Resistance in StaphylococcusAntibiotic Resistance in Bacteria