Nitazoxanide and related thiazolides induce cell death in cancer cells by targeting the 20S proteasome with novel binding modes
Zirui Lü, Xiaona Li, Kebin Li, Paola Ripani, Xiaomeng Shi, Fengrong Xu, Mopei Wang, Liangren Zhang, Thomas Brunner, Ping Xu, Yan Niu
Topics & Concepts
ProteasomeBortezomibNitazoxanideCell cycleProgrammed cell deathBiologyCancer cellApoptosisProteasome inhibitorCell cycle checkpointCancerCell growthCancer researchCell biologyImmunologyBiochemistryMultiple myelomaGeneticsUbiquitin and proteasome pathwaysHistone Deacetylase Inhibitors ResearchAutophagy in Disease and Therapy