3D-QSAR and Pharmacophore modeling of 3,5-disubstituted indole derivatives as Pim kinase inhibitors
Bhushan D. Varpe, Shailaja B. Jadhav, Bandoo C. Chatale, Anil S. Mali, Shravan Y. Jadhav, Amol A. Kulkarni
Topics & Concepts
PharmacophoreQuantitative structure–activity relationshipADMEChemistryIndole testIn silicoStereochemistryComputational chemistryLigand (biochemistry)Hydrogen bondMolecular modelCombinatorial chemistryMoleculeOrganic chemistryBiochemistryIn vitroReceptorGeneCancer Mechanisms and TherapySynthesis and biological activityComputational Drug Discovery Methods