Nanoparticles Yield Increased Drug Uptake and Therapeutic Efficacy upon Sequential Near-Infrared Irradiation
Dong Luo, Xinning Wang, Ethan Walker, Jing Wang, Sarah E. Springer, Jason Lou, Gopalakrishnan Ramamurthy, Clemens Burda, James P. Basilion
Abstract
, the targeted AuNPs show excellent selectivity for PSMA-positive tumor cells. Triggered release of the therapeutic, Pc158, followed by sequential photodynamic therapy (PDT) results in significant inhibition of tumor growth. Further, we demonstrate that multiple sequential PDT greatly enhances nanoparticle uptake and therapeutic efficacy. PSMA is highly expressed in the neovasculature of most other solid tumors in humans, as well as PCa, making this approach of great practical interest for precision PDT in a wide range of cancers.
Topics & Concepts
Photodynamic therapyIn vivoCancer researchColloidal goldNanoparticleProstate cancerNanomedicineMaterials scienceTherapeutic indexIn vitroCancer cellDrugCancerNanotechnologyChemistryMedicinePharmacologyBiochemistryBiologyInternal medicineBiotechnologyOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesCancer, Hypoxia, and Metabolism