Exosomal long non-coding RNA UCA1 functions as growth inhibitor in esophageal cancer
Zijiang Zhu, Huilin Wang, Yao Pang, Hongxia Hu, Hongyi Zhang, Wenhao Wang
Abstract
PURPOSE: Esophageal cancer is a highly lethal and broad-spreading malignant tumor worldwide. Exosome-carrying lncRNAs play an essential role in the pathogenesis of various cancers. RESULTS: . Furthermore, exosomal UCA1 could directly target miRNA-613 in esophageal cancer cells. CONCLUSIONS: , and might be a promising biomarker for esophageal cancer. PATIENT AND METHODS: .
Topics & Concepts
Esophageal cancerMicrovesiclesCancer researchExosomeBiomarkerCarcinogenesisCancerIn vivoMedicinemicroRNABiologyInternal medicineBiochemistryGeneBiotechnologyCancer-related molecular mechanisms researchExtracellular vesicles in diseaseCircular RNAs in diseases