Relevance of circulating MiRNA-21 and MiRNA-181 in prediction of glioblastoma multiforme prognosis
Esraa M. Labib, Lobna R. Ezz El Arab, Hala Ghanem, Rasha E. Hassan, Menha Swellam
Abstract
BACKGROUND: Authors aimed to investigate the clinical role of miR-21 and miR-181 among glioblastoma multiforme (GBM) patients. MATERIALS AND METHODS: Expression for both miRs were detected in blood samples from newly diagnosed twenty GBM patients before and after treatment along with 20 healthy individuals using QPCR technology. RESULTS: MiR-21 reported increase expression while miR-181 reported decreased expression in GBM patients. Expression of miR-21 was up-regulated in GBM patients older than 60 years and frontal mass with tumor size > 5 cm while miR-181 expression was down-regulated among them. Worse PFS and OS reported increase in miR-21 expression and decrease in miR-181 expression. CONCLUSION: Detection of miR-21 and miR-181 expression levels may be a potential diagnostic and predictors for GBM prognosis.