Structure-guided semi-rational design of an imine reductase for enantio-complementary synthesis of pyrrolidinamine
Jun Zhang, Yaqing Ma, Fangfang Zhu, Jinping Bao, Qiaqing Wu, Shu‐Shan Gao, Chengsen Cui
Abstract
In this study, engineered imine reductases (IREDs) of IRED M5, originally from Actinoalloteichus hymeniacidonis , were obtained through structure-guided semi-rational design.
Topics & Concepts
StereoselectivityChemistryMoietyImineSelectivityStereochemistryRational designMutagenesisCombinatorial chemistryKetoneOrganic chemistryBiochemistryMutationNanotechnologyCatalysisGeneMaterials scienceEnzyme Catalysis and ImmobilizationChemical Synthesis and AnalysisBiochemical and Molecular Research