Constructive On-DNA Abramov Reaction and Pudovik Reaction for DEL Synthesis
Zhaomei Sun, Lingqian Xiao, Yahui Chen, Jiangying Wang, Fanming Zeng, Huanqing Zhang, Jie Zhang, Kexin Yang, Yun Jin Hu
Abstract
Organophosphonic compounds are distinctive among natural products in terms of stability and mimicry. Numerous synthetic organophosphonic compounds, including pamidronic acid, fosmidromycin, and zoledronic acid, are approved drugs. DNA encoded library technology (DELT) is a well-established platform for identifying small molecule recognition to target protein of interest (POI). Therefore, it is imperative to create an efficient procedure for the on-DNA synthesis of α-hydroxy phosphonates for DEL builds.
Topics & Concepts
DNAComputer scienceConstructiveChemistryComputational biologyCombinatorial chemistryBiochemistryProgramming languageBiologyProcess (computing)Chemical Synthesis and AnalysisClick Chemistry and ApplicationsRNA and protein synthesis mechanisms