Long noncoding RNA <i>SNHG12</i> integrates a DNA-PK–mediated DNA damage response and vascular senescence
Stefan Haemmig, Dafeng Yang, Xinghui Sun, Debapria Das, Siavash Ghaffari, Roberto Molinaro, Lei Chen, Yihuan Deng, Dan Freeman, Norman Moullan, Yevgenia Tesmenitsky, Akm Khyrul Wara, Viorel Simion, Eugenia Shvartz, James F. Lee, Tianlun Yang, Galina Sukova, Jarrod A. Marto, Peter H. Stone, Warren L. Lee, Johan Auwerx, Peter Libby, Mark W. Feinberg
Abstract
expression was also reduced in pig and human atherosclerotic specimens and correlated inversely with DNA damage and senescent markers. These findings reveal a role for this lncRNA in regulating DNA damage repair in the vessel wall and may have implications for chronic vascular disease states and aging.
Topics & Concepts
DNA damageBiologySenescenceGene knockdownTelomereCancer researchCell biologyDNA repairDNAGeneGeneticsCancer-related molecular mechanisms researchAtherosclerosis and Cardiovascular Diseases