Computing Arithmetic Functions Using Immobilised Enzymatic Reaction Networks
Nikita M. Ivanov, Mathieu G. Baltussen, Cristina Lía Fernández Regueiro, Max T. G. M. Derks, Wilhelm T. S. Huck
Abstract
Living systems use enzymatic reaction networks to process biochemical information and make decisions in response to external or internal stimuli. Herein, we present a modular and reusable platform for molecular information processing using enzymes immobilised in hydrogel beads and compartmentalised in a continuous stirred tank reactor. We demonstrate how this setup allows us to perform simple arithmetic operations, such as addition, subtraction and multiplication, using various concentrations of substrates or inhibitors as inputs and the production of a fluorescent molecule as the readout.
Topics & Concepts
Modular designMultiplication (music)SubtractionComputer scienceCombinatorial chemistryEnzymeSimple (philosophy)Biological systemProcess (computing)ChemistryArithmeticMathematicsOrganic chemistryBiologyCombinatoricsOperating systemPhilosophyEpistemologyAdvanced biosensing and bioanalysis techniquesMolecular Junctions and NanostructuresElectrowetting and Microfluidic Technologies