Cu<sup>II</sup>-mediated DNA base pairing of a triazole-4-carboxylate nucleoside prepared by click chemistry
Lingyun Hu, Yusuke Takezawa, Mitsuhiko Shionoya
Abstract
Triazole-4-carboxylate nucleosides synthesized by the click reaction form a Cu II -mediated artificial base pair within DNA duplexes and stabilize the duplex in a Cu II -specific manner.
Topics & Concepts
Click chemistryCarboxylateChemistryBase pairNucleosideDNAPairingTriazoleCombinatorial chemistryNucleobaseDuplex (building)MetalLigand (biochemistry)Base (topology)StereochemistryOrganic chemistryBiochemistryReceptorMathematicsPhysicsMathematical analysisQuantum mechanicsSuperconductivityClick Chemistry and ApplicationsAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid Chemistry