Generation of a Key Synthon of Indole Alkaloid Synthesis by Palladium(II)‐Catalyzed Indole 2‐Methylenephosphorylation
Yuan Niu, Peng‐Bo Bai, Qinxin Lou, Shang‐Dong Yang
Abstract
Abstract A palladium‐catalyzed Catellani‐type reaction of indole with diethyl (iodomethyl)phosphonate has been developed. This new protocol provides an efficient and concise route to 2‐methylene phosphonate indoles, which are key synthons for the construction of indole alkaloids.
Topics & Concepts
SynthonIndole testChemistryPhosphonatePalladiumCatalysisMethyleneCombinatorial chemistryIndole alkaloidOrganic chemistryCatalytic C–H Functionalization MethodsSynthesis of Indole DerivativesSynthesis and Biological Activity