The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response
Harald Schuhwerk, Julia Kleemann, Pooja Gupta, Ruthger van Roey, Isabell Armstark, Martina Kreileder, Nora Feldker, Vignesh Ramesh, Yussuf Hajjaj, Kathrin Fuchs, Mousumi Mahapatro, Mojca Hriberšek, Marco Volante, Arwin Groenewoud, Felix B. Engel, Paolo Ceppi, Markus Eckstein, Arndt Hartmann, Fabian Müller, Torsten Kroll, Marc P. Stemmler, Simone Brabletz, Thomas Brabletz
Abstract
cells. Our study thus highlights the translationally relevant intercept of the DDR and EMT.
Topics & Concepts
BiologyDNA damageTranscription factorCell cycleCell biologyDNA repairCancer researchPopulationCellDNAGeneticsGeneMedicineEnvironmental healthCancer Cells and MetastasisDNA Repair MechanismsEpigenetics and DNA Methylation