Hippo pathway activation mediates chemotherapy-induced anti-cancer effect and cardiomyopathy through causing mitochondrial damage and dysfunction
Gang She, Jin-Chan Du, Wei Wu, Tian-Tian Pu, Yu Zhang, Ru‐Yue Bai, Yi Zhang, Zheng‐Da Pang, Hui‐Fang Wang, Yujie Ren, Junichi Sadoshima, Xiu‐Ling Deng, Xiao‐Jun Du
Abstract
Anti-cancer action of both DOX and verteporfin is associated with Hippo pathway activation. Such action on cardiac Hippo pathway mediates mitochondrial damage and cardiomyopathy.
Topics & Concepts
Hippo signaling pathwayCancer researchVerteporfinMedicineCancerCardiomyopathyMitochondrionBiologyInternal medicineKinaseCell biologyHeart failureSurgeryVisual acuityChoroidal neovascularizationHippo pathway signaling and YAP/TAZCell death mechanisms and regulationPI3K/AKT/mTOR signaling in cancer