Metal-Catalyst-Free Radical Cyclization of 1,6-Enynes for the Selective and Switchable Synthesis of Lactams in Water

Abstract

Three types of novel radical cyclization of 1,6-enynes with sulfonyl hydrazides have been presented, which provided convenient synthetic approaches for accessing five-membered cyclic lactams, five-membered cyclic lactams containing C–I bond, and six-membered cyclic lactams. Notably, these transformations are implemented in metal-catalyst-free systems, in which three classes of important lactam derivatives were synthesized with selectivity and controllability from the same substrate using water as the green solvent.

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