Synthesis, anticancer evaluation, CDK2 inhibition, and apoptotic activity assessment with molecular docking modeling of new class of pyrazolo[1,5-a]pyrimidines
Nadia H. Metwally, Mona Said Mohamed, Emad Abdullah Deeb
Topics & Concepts
HeLaPyrimidineChemistryDocking (animal)Lipinski's rule of fiveIC50StereochemistryApoptosisCell cycleCyclin-dependent kinaseCombinatorial chemistryMCF-7In silicoIn vitroBiochemistryCancer cellCancerBiologyGeneticsGeneHuman breastNursingMedicineCancer therapeutics and mechanismsAdvanced Breast Cancer TherapiesCancer Mechanisms and Therapy