Deletion of renal Nedd4-2 abolishes the effect of high sodium intake (HS) on Kir4.1, ENaC, and NCC and causes hypokalemia during high HS
Dandan Zhang, Xin‐Peng Duan, Yu Xiao, Peng Wu, Zhong‐Xiuzi Gao, Wen‐Hui Wang, Dao‐Hong Lin
Abstract
The present study suggests that Nedd4-2 is involved in mediating the inhibitory effect of high salt (HS) diet on Kir4.1/kir5.1 in the distal convoluted tubule, NaCl cotransporter function, and epithelial Na + channel activity and that Nedd4-2 plays an essential role in maintaining K + homeostasis in response to a long-term HS diet. This suggests the possibility that HS intake could lead to hypokalemia in subjects lacking proper Nedd4-2 E3 ubiquitin ligase activity in aldosterone-sensitive distal nephron.
Topics & Concepts
Distal convoluted tubuleEpithelial sodium channelEndocrinologyInternal medicineChemistryAldosteroneKidneyNatriuresisReabsorptionSGK1SodiumBiologyMedicineOrganic chemistryGlucocorticoidIon Transport and Channel RegulationHormonal Regulation and HypertensionApelin-related biomedical research