A multifaceted biomimetic periosteum with a lamellar architecture and osteogenic/angiogenic dual bioactivities
Yonggang Zhao, Xiong Yang, Jingchuan Zheng, Wenyao Kongling, Junlin Chen, Chengli Li, Peilun Hu, Shuhui Yang, Xiumei Wang
Abstract
evaluations in a rat cranial bone defect model including micro-CT morphology, histological staining, and immunohistochemical analysis showed that Mg-doped mineralized collagen-based AP (MgMC@AP) significantly facilitated cranial bone regeneration and fast vascularization. Our findings suggest that the AP mimicked the composition, lamellar structure, mechanical properties, and biological activities of natural periosteum/lamellae, showing great promise for bone tissue regeneration.
Topics & Concepts
PeriosteumLamellar structureCascadeDual (grammatical number)ChemistryNanotechnologyMaterials scienceBiophysicsCell biologyBiomedical engineeringAnatomyBiologyMedicineCrystallographyLiteratureArtChromatographyBone Tissue Engineering MaterialsCalcium Carbonate Crystallization and InhibitionPolymer Surface Interaction Studies