The lipoprotein NlpD in <i>Cronobacter sakazakii</i> responds to acid stress and regulates macrophage resistance and virulence by maintaining membrane integrity
Xuemeng Ji, Ping Lu, Juan Xue, Ning Zhao, Yan Zhang, Dong Lu, Xuejiao Zhang, Ping Li, Yaozhong Hu, Jin Wang, Bowei Zhang, Jingmin Liu, Huan Lv, Shuo Wang
Abstract
to survive under acid stress conditions. Considering that NlpD is a conserved lipoprotein located in the bacterial outer membrane, NlpD could be used as a target for drug development.
Topics & Concepts
Cronobacter sakazakiiVirulenceBiologyMicrobiologyVirulence factorBacterial outer membraneMutantPathogenPropidium iodideTransposon mutagenesisBacteriaTransposable elementBiochemistryGeneticsGeneEscherichia coliProgrammed cell deathApoptosisEnterobacteriaceae and Cronobacter ResearchBacteriophages and microbial interactionsParasitic Infections and Diagnostics