Boronic acid-containing diarylpyrimidine derivatives as novel HIV-1 NNRTIs: Design, synthesis and biological evaluation
Da Feng, Fenju Wei, Yanying Sun, Prem P. Sharma, Tao Zhang, Hao Lin, Brijesh Rathi, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu
Topics & Concepts
EC50ChemistryReverse transcriptaseBoronic acidReverse-transcriptase inhibitorIC50StereochemistryNucleosideNucleoside Reverse Transcriptase InhibitorCytotoxicityEnzymeHuman immunodeficiency virus (HIV)Combinatorial chemistryIn vitroVirologyBiochemistryBiologyRNAGeneHIV/AIDS drug development and treatmentPneumocystis jirovecii pneumonia detection and treatmentChemical Synthesis and Analysis