Pain induces stable, active microcircuits in the somatosensory cortex that provide a therapeutic target
Takuya Okada, Daisuke Kato, Yuki Nomura, Norihiko Obata, Xiangyu Quan, Akihito Morinaga, Hajime Yano, Zhongtian Guo, Yuki Aoyama, Yoshihisa Tachibana, Andrew J. Moorhouse, Osamu Matoba, Tetsuya Takiguchi, Satoshi Mizobuchi, Hiroaki Wake
Abstract
Upregulation of N-type Ca 2+ channel dependent subunits increases functional connections and synchronization for pain formation.
Topics & Concepts
Somatosensory systemDownregulation and upregulationNeuroscienceCortex (anatomy)Synchronization (alternating current)Channel (broadcasting)PsychologyChemistryComputer scienceBiochemistryComputer networkGenePain Mechanisms and TreatmentsIon channel regulation and functionNeuroscience and Neuropharmacology Research