Identification of novel prognosis-related genes in the endometrial cancer immune microenvironment
Jian Ma, Jingkai Zhang, Di Yang, Xiaoxin Ma
Abstract
mutational status. A search for LCK-related modules returned seven independent genetic predictors of survival in patients with endometrial cancer. The TIMER algorithm showed that the expression of these seven genes was positively correlated with the infiltration levels of six types of immune cells. The diagnostic value of these markers was validated using real-time quantitative PCR and immunohistochemical methods. Our results identified CD74, HLA-DRB5, CD52, HLA-DPB1 and HLA-DRB1 as possible valuable genetic markers for the diagnosis and prognosis of endometrial cancer and provided a theoretical basis for immunotherapy targets for its clinical treatment.
Topics & Concepts
Immune systemIdentification (biology)Endometrial cancerGeneTumor microenvironmentBiologyCancer researchComputational biologyCancerMedicineOncologyImmunologyGeneticsEcologyEndometrial and Cervical Cancer TreatmentsReproductive System and PregnancyCircular RNAs in diseases