Single-cell metabolomics by mass spectrometry: ready for primetime?
Congrou Zhang, Sylvia E. Le Dévédec, Ahmed Ali, Thomas Hankemeier
Abstract
Single-cell metabolomics (SCMs) is a powerful tool for studying cellular heterogeneity by providing insight into the differences between individual cells. With the development of a set of promising SCMs pipelines, this maturing technology is expected to be widely used in biomedical research. However, before SCMs is ready for primetime, there are some challenges to overcome. In this review, we summarize the trends and challenges in the development of SCMs. We also highlight the latest methodologies, applications, and sketch the perspective for integration with other omics and imaging approaches.
Topics & Concepts
MetabolomicsComputer scienceSketchData sciencePerspective (graphical)Computational biologyBiologyBioinformaticsArtificial intelligenceAlgorithmMetabolomics and Mass Spectrometry StudiesAdvanced Proteomics Techniques and ApplicationsCell Image Analysis Techniques