Calnexin promotes glioblastoma progression by inducing protective mitophagy through the MEK/ERK/BNIP3 pathway
Xuchen Liu, Jiangli Zhao, Sun Q, Zhiwei Xue, Ziyi Tang, Wenyu Liu, Junzhi Liu, Baojian Miao, Nan‐Wei Su, Yulong He, Yuehua Zhu, Bin Huang, Ning Yang, Chao Li, Jiwei Wang, Xinyu Wang
Abstract
Our findings indicate that CANX functions as an oncogene in GBM. We also characterize the CANX/MEK/ERK/BNIP3 mitophagy pathway, provide new insights into the molecular mechanism of GBM drug resistance, and identify a therapeutic target.
Topics & Concepts
MitophagyGlioblastomaCalnexinMAPK/ERK pathwayCancer researchCell biologyDownregulation and upregulationChemistrySignal transductionBiologyAutophagyApoptosisCalreticulinGeneEndoplasmic reticulumGeneticsConnexins and lens biologyRNA regulation and diseaseCalpain Protease Function and Regulation