Copper-Catalyzed Asymmetric Ring-Opening Reaction of Cyclic Diaryliodonium Salts with Imides
Fu Cheng, Dong-Sen Duan, Liming Jiang, Baosheng Li, Jiaxuan Wang, Yujia Zhou, He-Yu Jiao, Tao Wu, Dao‐Yong Zhu, Shao‐Hua Wang
Abstract
An efficient copper-catalyzed asymmetric ring-opening reaction of diaryliodonium salts with imides has been developed, affording a wide range of axially chiral 2-imidobiaryl compounds with excellent enantioselectivities and better convertibility. The potential utility of the current method has been supported by the synthesis of two known chiral ligands with better efficiency, which would be of great significance to the development of other catalytic asymmetric reactions.
Topics & Concepts
ChemistryCatalysisCopperCombinatorial chemistryRing (chemistry)ConvertibilityOrganic chemistryCurrencyEconomicsMonetary economicsAxial and Atropisomeric Chirality SynthesisAlkaloids: synthesis and pharmacologyAsymmetric Synthesis and Catalysis