Design, synthesis, and biological evaluation of quinoxalinone derivatives as potent BRD4 inhibitors
Kai-Yan Xu, Xueting Wang, Lei Cheng, Qi-Hang Cui, Jian-Tao Shi, Liwen Zhang, Shi‐Wu Chen
Topics & Concepts
ChemistryIC50OccludinLead compoundApoptosisBiochemistryPharmacologyIn vitroTight junctionMedicineProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways