Effects of gene polymorphisms on delayed MTX clearance, toxicity, and metabolomic changes after HD-MTX treatment in children with acute lymphoblastic leukemia
Yao Zhou, Haoping He, Luping Ding, Tianjiao Wang, Xiaomeng Liu, Minghao Zhang, Aijun Zhang, Jinqiu Fu
Topics & Concepts
Methylenetetrahydrofolate reductaseMedicineMethotrexateInternal medicineGastroenterologyGSTP1AntifolateThiopurine methyltransferasePharmacologyAdverse effectUnivariate analysisAntimetaboliteGenotypeMultivariate analysisDiseaseBiologyGeneticsGeneInflammatory bowel diseaseAcute Lymphoblastic Leukemia researchChildhood Cancer Survivors' Quality of LifeChemotherapy-induced organ toxicity mitigation