Ferroptosis, a therapeutic target for cardiovascular diseases, neurodegenerative diseases and cancer
Yinghui Li, Cui-Yun Liu, Bo Fang, Xinzhe Chen, Kai Wang, Hui Xin, Kun Wang, Sumin Yang
Abstract
The identification of ferroptosis represents a pivotal advancement in the field of cell death research, revealing an entirely novel mechanism of cellular demise and offering new insights into the initiation, progression, and therapeutic management of various diseases. Ferroptosis is predominantly induced by intracellular iron accumulation, lipid peroxidation, or impairments in the antioxidant defense system, culminating in membrane rupture and consequent cell death. Studies have associated ferroptosis with a wide range of diseases, and by enhancing our comprehension of its underlying mechanisms, we can formulate innovative therapeutic strategies, thereby providing renewed hope for patients.