Prussian blue nanozyme-mediated nanoscavenger ameliorates acute pancreatitis via inhibiting TLRs/NF-κB signaling pathway
Xue Xie, Jiulong Zhao, Wei Gao, Jie Chen, Bing Hu, Xiaojun Cai, Yuanyi Zheng
Abstract
The single-component, gram-level mass production, stable intrinsic biological activity, biosafety, and good therapeutic efficacy suggest the potential of PBzyme in the preventive treatment of AP. This study provides a foundation for the clinical application of PBzyme.
Topics & Concepts
Acute pancreatitisPrussian blueOxidative stressInflammationMedicineNF-κBPancreatitisInflammatory responseImmunologyInternal medicineChemistryElectrochemistryElectrodePhysical chemistryAdvanced Nanomaterials in CatalysisPancreatitis Pathology and TreatmentAbdominal vascular conditions and treatments