Biological implications of PTEN upregulation and altered sodium/iodide symporter intracellular distribution in resveratrol-suppressed anaplastic thyroid cancer cells
Le Xiong, Jun‐Hua Nie, Xiao-Min Lin, Jianbin Wu, Zhen Chen, Bo Xu, Jia Liu
Abstract
Objective: Anaplastic thyroid cancer/ATC is a highly aggressive malignancy with extremely poor prognosis. Resveratrol/Res promotes re-differentiation of cancer cells and exerts inhibitory effects on ATC cells. Sodium/iodide symporter/NIS and phosphate and tension homology deleted on chromsome ten/PTEN levels are positively correlated with the grade of thyroid cancer differentiation, while the impact of Res on them remain unknown.
Topics & Concepts
PTENAnaplastic thyroid cancerCancer researchSodium-iodide symporterThyroid cancerResveratrolApoptosisDownregulation and upregulationCancer cellSymporterCancerCell growthChemistryBiologyInternal medicineMedicinePI3K/AKT/mTOR pathwayBiochemistryGeneTransporterPI3K/AKT/mTOR signaling in cancerThyroid Cancer Diagnosis and Treatment