Increased photodynamic therapy sensitization in tumors using a nitric oxide-based nanoplatform with ATP-production blocking capability
Qinyanqiu Xiang, Bin Qiao, Yuanli Luo, Jin Cao, Kui Fan, Xinghua Hu, Lan Hao, Yang Cao, Qunxia Zhang, Zhigang Wang
Abstract
We show that this NO-based nanoplatform can be potentially used to alleviate hypoxia and sensitize tumor cells to amplify the efficacy of phototherapy guided by photoacoustic (PA) imaging.
Topics & Concepts
Photodynamic therapyNitric oxideChemistryIn vivoIntracellularTumor hypoxiaCancer researchCancer cellIn vitroHypoxia (environmental)BiophysicsSensitizationPharmacologyBiochemistryCell biologyCancerMedicineRadiation therapyOxygenBiologyImmunologyInternal medicineOrganic chemistryBiotechnologyNanoplatforms for cancer theranosticsCancer, Hypoxia, and MetabolismPhotodynamic Therapy Research Studies