The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2
Nilüfer N. Turan, Karni S. Moshal, Karim Roder, Brett Baggett, Anatoli Y. Kabakov, Saroj Dhakal, Ryota Teramoto, David Y. Chiang, Mingwang Zhong, An Xie, Yichun Lu, Samuel C. Dudley, Calum A. MacRae, Alain Karma, Gideon Koren
Abstract
homeostasis are responsible for the surprisingly modest action potential duration shortening. These computational data thus corroborate findings from several genome-wide association studies that associated LITAF with QT interval variation.
Topics & Concepts
NEDD4HEK 293 cellsNav1.5UbiquitinUbiquitin ligaseRegulatorCell biologyChemistrySodium channelCardiac action potentialEndosomeMolecular biologyBiologyCancer researchGeneBiochemistryElectrophysiologyIntracellularSodiumNeuroscienceOrganic chemistryRepolarizationCardiac electrophysiology and arrhythmiasReceptor Mechanisms and SignalingIon channel regulation and function